Independent risk factors for sepsis after ureteroscopy
WANG Jingshen1, HAO Zhiqiang1, WANG Qinzhang1, ZHENG Liying2, HUO Wangsheng3, LIU Yi4, QIAN Biao2
1Department of Urology, the First Affiliated Hospital of Shihezi University School of Medicine, Shihezi 832000; 2Department of Urology, the First Affiliated Hospital of Gannan Medical College; 3Department of Urology, Hongxing Hospital, 13th Division, Xinjiang Production and Construction Corps; 4Department of Urology, 17th Division, Xinjiang Production and Construction Corps
Abstract:Objective: To explore the independent risk factors and treatment strategies for the occurrence of sepsis after ureteroscopy. Methods: A retrospective analysis was performed on 119 cases of ureteroscope lithotripsy from January 2015 to June 2018 in the First Affiliated Hospital of Shihezi University School of Medicine. There were 13 cases of postoperative sepsis, and no sepsis occurred in 106 cases. The patient's age, gender, diabetes, preoperative urine culture results, stone size, history of calculus surgery, preoperative placement of double J tube, operation time and other risk factors were collected. According to the data type, t test or χ2 test was used to perform single factor analysis, and the t value or χ2 value and P value of each risk factor were calculated. P <0.05 was statistically significant. For multivariate analysis, binary logistic regression analysis was used to calculate the P value, OR value and 95% CI value of each risk factor. P <0.05 was statistically significant. Results: One-way analysis showed that there were significant differences in age, urine culture positivity, urine routine positivity, female, diabetes, and operation time (P<0.05). Multivariate analysis showed age [OR 1.106 (1.012, 1.208)] and female [OR 7.263 (1.2, 43.975)], operative time >60 min [OR 10.469 (1.053, 104.08)] were independent risk factors. Conclusion: Age, female, and operation time >60 min are independent risk factors for sepsis after ureteroscopy.
[1] 王立敏,王婷,贺盛.输尿管镜下钬激光治疗输尿管结石的围手术期护理.中华腔镜外科杂志(电子版),2012,5(4):329-331. [2] 陆巍,毛宗福.输尿管软镜碎石术应用与发展探索.中国卫生管理标准,2018,9(21):53-56. [3] AURITI C, FISCARELLI E, RONCHETTI MP, et al.Procalcitonin in detecting neonatal nosocomial sepsis. Arch Dis Child Fetal Neonatal Ed, 2012,97(5):F368-F370. [4] KAUKONEN KM, BAILEY M, PILCHER D, et al.The systemic inflammatory response syndrome criteria and their differential association with mortality. J Crit Care, 2018,46(11):29-36. [5] 那彦群,叶章群,孙光,等.中国泌尿外科疾病诊断治疗指南(2014版).北京:人民卫生出版社,2014:192-193. [6] 蒋昌毅,叶枝能,王海峰,等.组合式输尿管软镜钬激光治疗儿童上尿路结石.中华腔镜外科杂志(电子版),2018,11(2):123-125. [7] ZHANG Y, YU CF, JIN SH, et al.A prospective comparative study between minimally invasive percutaneous nephrolithotomy in supine position and flexible ureteroscopy in the management of single large stone in the proximal ureter. Urology, 2014,83(5):999-1002. [8] 赵振华,赵国平,郑东升,等.输尿管软镜碎石术后尿脓毒血症的危险因素分析.中华腔镜泌尿外科杂志(电子版),2018,12(1):16-19. [9] LEVY MM, ARTIGAS A, PHILLIPS GS, et al.Outcomes of the surviving sepsis campaign in intensive care units in the USA and Europe: a prospective cohort study. Lancet Infect Dis, 2012,12(12):919-924. [10] 吴文校,马戟,林良森.经尿道输尿管镜下尿道会师术在尿道损伤治疗中的临床应用.中华腔镜泌尿外科杂志(电子版),2013,7(2):115-117. [11] 刘绪堃,汪涛,程耿.输尿管镜下尿道会师术治疗尿道损伤.中国医师进修杂志,2014,37(14):16-19. [12] COLMAN M, WRIGHT A, GRUEN G, et al.Prolonged operative time increases infection rate in tibial plateau fractures. Injury, 2013,44(2):249-252. [13] 施小东,程跃,邱中笑,等.电子输尿管软镜碎石术治疗肾结石疗效观察.现代实用医学,2010,22(9):1018-1019. [14] BECKER KL, SNIDER R, NYLEN ES.Procalcitonin assay in systemic inflammation, infection, and sepsis: clinical utility and limitations. Crit Care Med, 2008,36(3):941-952. [15] NAPOLITANO LM.Sspsis 2018: definitions and guideline changes. Surg Infect (Larchmt), 2018,19(2):117-125. [16] KUMAR S, BAG S, GANESAMONI R, et al.Risk factors for urosepsis following percutaneous nephrolithotomy: role of 1 week of nitrofurantoin in reducing the risk of urosepsis. Urol Res, 2012,40(1):79-86. [17] 孙春雷,谷欣权,高吉,等.输尿管软镜碎石术后并发重症感染的相关因素及防治策略.中国老年学杂志,2016,36(11):2710-2711. [18] 杨嗣星. 输尿管软镜钬激光碎石术肾盂内压检测方法及意义.临床外科杂志,2014,32(11):799-801. [19] WAGENLEHNER FM, LICHTENSTERN C, ROLFES C, et al.Diagnosis and management for urosepsis. Int J Urol, 2013,20(10):963-970. [20] GIAMARELLOS-BOURBOULIS EJ, MEGA A, GRECKA P, et al.Procalcitonin: a marker to clearly differentiate systemic inflammatory response syndrome and sepsis in the critically ill patient? Intensive Care Med, 2002,28(9):1351-1356. [21] 夏宝山,任维果,章建胜,等.输尿管软镜钬激光碎石术后尿原性脓毒血症8例分析.南通大学学报(医学版),2018,38(5):390-391. [22] NEVO A, MANO R, BANIEL J, et al.Ureteric stent dwelling time: a risk factor for post-ureteroscopy sepsis. BJU Int, 2017,120(1):117-122.