Abstract：Objective: To evaluate risk factors of percutaneous nephrolithotripsy-induced urosepsis, and put forward specific control measures to improve the safety of the operation. Methods: The clinical data of 489 cases undergoing percutaneous nephrolithotripsy admitted at our hospital from January 2012 to February 2017 were retrospectively analyzed. The clinical data including gender, age, preoperative urinary tract infection and operative time were collected. The incidence of urosepsis was statistically analyzed. The risk factors of urosepsis were analyzed by the Logistic regression analysis. Results: Of 489 cases given percutaneous nephrolithotripsy, 11 patients were diagnosed as having urosepsis with the incidence being 2.2%. The Logistic regression analysis revealed age of ≥60 years, preoperative positive urine culture, stone diameter of ≥2.5 cm, staghorn stones, and operation time ≥90 min were risk factors of urosepsis (P<0.05). Eleven patients with urosepsis were treated by antiinfection, oxygen supply, fluid resuscitation, acid suppressive drugs, and cured. Conclusions: age of ≥60 years, preoperative positive urine culture, stone diameter of ≥2.5 cm, staghorn stones, and operation time ≥90 min were risk factors of urosepsis. Antiinfection, oxygen supply, fluid resuscitation and acid suppressive drugs can be helpful for recovery of patients.
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