Abstract：Objective: To explore the clinical value of tamsulosin hydrochloride sustainedrelease capsule in the treatment of upper ureteral calculi in different parts by ureteroscopy. Methods: The clinical data of 178 patients with upper ureteral calculi treated by ureteroscopy in our hospital from March 2016 to June 2021 were analyzed retrospectively. According to whether tamsulosin hydrochloride sustainedrelease capsule was taken orally before operation, they were divided into drug group （n=93） and control group （n=85）. The success rate of operation, the visible rate of renal calices and the incidence of intraoperative "holding ureteroscopy" were compared and analyzed between the two groups. Then the two groups were divided into upper, middle and lower parts of the upper ureter according to the different positions of the stones, and the above indexes were compared and analyzed again. Results: The success rate of operation and the visible rate of renal calices in the medication group were significantly higher than those in the control group （P<0.01）, while the incidence of intraoperative "holding ureteroscopy" was lower than that in the control group （P<0.05）. The upper ureteral calculi is bounded by the lower pole of the kidney, the transverse process of L4 and the upper edge of sacroiliac joint, and the ureters were divided into upper, middle and lower parts. For upper and lower parts of upper ureteral calculi, there was no significant difference in the success rate of operation, the visible rate of renal calices and the intraoperative "holding ureteroscopy" rate between the two groups （P>0.05）. But for middle pats of upper ureteral calculi, there was differet results. The success rate of operation and the visible rate of renal calices in the medication group were significantly higher than those in the control group （P<0.05）, and the incidence of intraoperative "holding ureteroscopy" was significantly lower than that in the control group （P<0.05）. Conclusion: Tamsulosin hydrochloride sustainedrelease capsule can relax ureteral smooth muscle, increase the success rate of rigid ureteroscopy for upper ureteral calculi, and reduce the risk of "holding ureteroscopy" during operation. Especially for stones located between the lower pole of the kidney and the transverse process of L4.
赵豫波, 王毅, 张川, 贾卓敏, 王希友, 谢常亮, 陈安龙, 徐衍盛, 金一鹏. 盐酸坦索罗辛缓释胶囊对输尿管硬镜治疗不同部位输尿管上段结石的价值研究[J]. 微创泌尿外科杂志, 2022, 11(6): 381-385.
Zhao Yubo, Wang Yi, Zhang Chuan, Jia Zhuomin, Wang Xiyou, Xie Changliang, Chen Anlong, Xu Yansheng, Jin Yipeng. Clinical value of tamsulosin hydrochloride sustained release capsule in the treatment of upper ureteral calculi in different parts by ureteroscopy. JOURNAL OF MINIMALLY INVASIVE UROLOGY, 2022, 11(6): 381-385.
