Abstract：Objective: To investiate the clinicopathologic features of mucinous tubular and spindle cell carcinoma (MTSCC) of the kidney, an extremely rare carcinoma. Methods: The clinical data about manifestations, diagnosis, surgical approaches and pathological features of 2 cases of MTSCC treated from January 2006 to February 2014 were analyzed retrospectively. The related literatures were reviewd. Results: Both of the patients in this study were female: one was 47 years old, and the other was 57. No clinical symptoms were found. The disease was not detected until B ultrasound tests were performed during health examination. The tumors were characterized with one single mass on one kidney with diameter around 4 cm. Imaging information showed that the tumors were short of blood supply. Both of the cases were treated by retroperitoneoscopic radical nephrectomy. Postoperative pathological examination showed that CK7 and CK19 were positive in both cases, CD10 positive in one case, and negative in one negative. The follow-up period was 6 years and 1 year respectively. No recurrence or metastasis was observed. Conclusions: MTSCC is a rare low-grade malignant renal epithelial carcinoma with a relatively good prognosis. MTSCC can be treated by radical nephrectomy and nephron-sparing surgery, and the latter is recommended if possible. Minimally invasive surgery is better than open surgery. Follow-up should be emphasized on because metastasis was reported in some cases with or without sarcomatoid change.
刘侃,赵超飞,罗国雄,孟庆禹,姚远新,马明辉,王雷,武翀,张旭. 肾黏液样小管状和梭形细胞癌2例病例报告并文献复习[J]. 微创泌尿外科杂志, 2015, 4(1): 40-43.
Liu Kan, Zhao Chaofei, Luo Guoxiong, Meng Qingyu, Yao Yuanxin,Ma Minghui, Wang Lei, Wu Chong, Zhang Xu. Mucinous tubular and spindle cell carcinoma of the kidney: a report of 2 cases and literature review. JOURNAL OF MINIMALLY INVASIVE UROLOGY, 2015, 4(1): 40-43.
[1] Kuroda N, Toi M, Hiroi M, et al. Review of mucinous tubular and spindle-cell carcinoma of the kidney with a focus on clinical and pathobiological aspects. Histol Histopathol, 2005, 20(1):221-224. [2]Yang G, Breyer BN, Weiss DA, et al. Mucinous tubular and spindle cell carcinoma of the kidney. J Urol, 2010,183(2):738-739 [3]Sun N, Fu Y, Wang Y, et al. Mucinous tubular and spindle cell carcinoma of the kidney: a case report and review of the literature, Oncol Lett, 2014,7(3):811-814. [4]Kenney PA, Vikram R, Prasad SR, et al. Mucinous tubular and spindle cell carcinoma (MTSCC) of the kidney: a detailed study of radiological, pathological and clinical outcomes. BJU Int, 2014.Doi:10.1111/bju.12992. [5]Alexiev BA, Burke AP, Drachenberg CB, et al. Mucinous tubular and spindle cell carcinoma of the kidney with prominent papillary component, a non-classic morphologic variant. A histologic, immunohistochemical, electron microscopic and fluorescence in situ hybridization study. Pathol Res Pract, 2014,210(7):454-458. [6]Paner GP, Srigley JR, Radhakrishnan A, et al. Immunohistochemical analysis of mucinous tubular and spindle cell carcinoma and papillary renal cell carcinoma of the kidney: significant immunophenotypic overlap warrants diagnostic caution. Am J Surg Pathol, 2006,30(1):13-19. [7]Cossu Rocca P, EBle JN, Delahunt B, et al. Renal mucinous tubular and spindle carcinoma lacks the gains of chromosomes 7 and 17 and losses of chromosome Y that are prevalent in papillary renal cell carcinoma. Mod Pathol, 2006,19(4):488-493. [8]Zhu Q, Zhu W, Wang Z, et al. Clinical and CT imaging features of mucinous tubular and spindle cell carcinoma. Chin Med J (Engl), 2014,127(7):1278-1283. [9]Zhang Q, Wang W, Zhang S, et al. Mucinous tubular and spindle cell carcinoma of the kidney: the contrast-enhanced ultrasonography and CT features of six cases and review of the literature. Int Urol Nephrol, 2014,46(12):2311-2317. [10]Oliva MR, Glickman JN, Zou KH, et al. Renal cell carcinoma: T1 and T2 signal intensity characteristics of papillary and clear cell types correlated with pathology. Am J Roentgenol, 2009,192(6):1524-1530. [11]Ozturk H. 18F-fluorodeoxyglucose-positron-emission tomography/computed tomography staging of mucinous tubular and spindle cell carcinoma of the kidney. Indian J Nucl Med, 2015,30(1):68-71. [12]Bertagna F, Motta F, Bertoli M, et al. Role of F18-FDG-PET/CT in restaging patients affected by renal carcinoma. Nucl Med Rev Cent East Eur, 2013,16(1):3-8. [13]Porpiglia F, Volpe A, Billia M, et al. Laparoscopic versus open partial nephrectomy: analysis of the current literature. Eur Urol, 2008,53(4):732-742. [14]Kaouk JH, Hillyer SP, Autorino R, et al. 252 robotic partial nephrectomies: evolving renorrhaphy technique and surgical outcomes at a single institution. Urology, 2011,78(6):1338-1344. [15]Marks-Jones DA, Zynger DL, Parwani AV, et al. Fine needle aspiration biopsy of renal mucinous tubular and spindle cell carcinoma: report of two cases. Diagn Cytopatho, 2010,38(1):51-55. [16]Dhillon J, Amin MB, Selbs E, et al. Mucinous tubular and spindle cell carcinoma of the kidney with sarcomatoid change. Am J Surg Pathol, 2009,33(1):44-49. [17]Thway K, du Parcq J, Larkin JM, et al. Metastatic renal mucinous tubular and spindle cell carcinoma. Atypical behavior of a rare, morphologically bland tumor.Ann Diagn Pathol, 2012,16(5):407-410. [18]Ursani NA, Robertson AR, Schieman SM, et al. Mucinous tubular and spindle cell carcinoma of kidney without sarcomatoid change showing metastases to liver and retroperitoneal lymph node. Hum Pathol, 2011,42(3):444-448.
