Abstract：Objective： To observe the curative effectiveness of nephron sparing surgery for renal tumors, and analyze its influence on serum cortisol, urokinase-type plasminogen activator (uPA), vascular endothelial growth factor (VEGF) and T cell subsets. Methods： Eighty-four patients with renal tumor who were admitted to the hospital were selected, and all of them were treated with nephron sparing surgery. They were divided into the laparoscopic group (treated with laparoscopic nephron sparing surgery, n=46) and the open group (treated with conventional open surgery, n=38) according to different surgical procedures. Changes in levels of serum cortisol, uPA, VEGF and T cell subsets (CD3+, CD4+, CD4+/CD8+) before and after surgery, and postoperative recovery (postoperative drainage volume, recovery time of gastrointestinal function, hospital stay) were compared between the two groups. Results： There was no significant difference in postoperative drainage volume between the two groups (P > 0.05). The recovery time of gastrointestinal function and hospitalization time in laparoscopic group were significantly shorter than those in open group (P < 0.05). After surgery, levels of serum cortisol, uPA and VEGF were significantly lower (P < 0.05), while CD3+, CD4+ and CD4+/CD8+ were significantly higher (P < 0.05) in laparoscopic group than those in open group. Conclusion： Although operation time of laparoscopic NSS is longer than that of open NSS, blood loss of the former is less, which is conductive to improving cortisol secretion in perioperative period, reducing uPA and VEGF levels, reducing the influence of surgery on patients' immune function, and shortening recovery process.
凌强, 蓝建华, 杨海. 保留肾单位手术治疗肾肿瘤的疗效及对患者血清皮质醇、uPA、VEGF和T细胞亚群的影响[J]. 微创泌尿外科杂志, 2020, 9(1): 23-26.
LING Qiang, LAN Jianhua, YANG Hai. Curative effectiveness of nephron sparing surgery for renal tumors and its influence on serum cortisol, uPA, VEGF and T cell subsets. JOURNAL OF MINIMALLY INVASIVE UROLOGY, 2020, 9(1): 23-26.
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