Abstract：Objective： To investigate the differences in curative effect between transurethral en-bloc resection of bladder tumor （HoLERBT） and transurethral plasmakinetic resection of bladder tumor （TUPKBT） for non-muscular invasive bladder cancer （NMIBC）. Methods： 102 patients with NMIBC were selected for surgical treatment. According to the surgical methods, 52 patients who were treated with HoLERBT served as HoLERBT group and 50 patients who were treated with TUPKBT served as TUPKBT group. The length of operation, reduction of hemoglobin, rate of muscle layer in excised lesions, postoperative complications and 2-year recurrence rate between two groups were compared. The serum levels of Cyfra21-1 and urine NMP-22 were observed before and after operation. Results： Compared with TUPKBT group, the operation duration, urinary catheter indwelling time and hospital stay in HoLERBT group were significantly shortened （P < 0.05）. The obturator nerve reflex, complication rate and recurrence rate were also significantly reduced in HoLERBT group （P < 0.05）. By pathological examination, the rate of muscle layer in resected tissue of HoLERBT group was significantly higher than in TUPKBT group （P < 0.05）. Three months after the operation, the levels of serum Cyfra21-1 and urine NMP-22 in two groups were significantly reduced, and those in the HoLERBT group were significantly lower than in TUPKBT group （P < 0.05）. Conclusion： The effect of HoLERBT on NMIBC is significant, the postoperative recovery is fast, the tumor marker level can be effectively reduced, and the complication and recurrence rate can be reduced.
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