Establishment of a canine model of inferior vena cava progressive obstruction at the level of renal hilus
CHEN Changyu1, 2, HUANG Qingbo1, LI Qiuyang3, PENG Cheng1, DU Songliang1, WU Shengpan1, SHEN Donglai1, GU Liangyou1, NIU Shaoxi1, YU Yao1, 2, WANG Haiyi4, LIU Fengyong5, ZHANG Xu1, WANG Baojun1, MA Xin1
1Department of Urology, Chinese PLA General Hospital, Beijing 100853, China; 2School of Medicine, Nankai University; 3Department of Ultrasound, Chinese PLA General Hospital; 4Department of Radiology, Chinese PLA General Hospital; 5Department of Interventional Radiology, Chinese PLA General Hospital
Abstract：Objective： To explore an efficient and stable method for the establishment of a canine model of inferior vena cava progressive obstruction at renal hilus level. Methods: The model was established in 2 Beagle dogs by encircling an ameroid constrictor on the inferior vena cava, which was 2 cm above the entrance of the renal vein. Ultrasound examinations were performed weekly after surgery to observe the size and texture of the kidney, the position of the placed ameroid constrictor, the diameter of the inferior vena cava, and the blood flow velocity. Six weeks after surgery, an inferior vena cava angiography was performed to observe the establishment of the collateral circulation. Results: Ultrasound examinations showed that the diameter of the inferior vena cava gradually increased and the flow rate slowed after the surgery operation. Inferior vena cava angiography revealed a significant collateral circulation in all Beagle dogs. Conclusion: A canine model of inferior vena cava progressive obstruction at the level of renal hilus was successfully established by using the ameroid constrictors.
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