Abstract：Objective: To investigate reasonable and effective diagnosis and treatment of penile cancer. Methods: The clinical data of 149 patients with penile cancer treated from January 2000 to December 2014 were analyzed retrospectively. Results: There were 121 cases of squamous cell carcinoma, 13 cases of malignant change of papilloma, 9 cases of verrucous carcinoma, 4 cases of Paget disease, and 2 cases of malignant melanoma. 115 cases received partial penectomy, 22 cases received total penectomy and perineal urethrostomy, and 34 cases received inguinal lymphadenectomy. 129 cases were regularly followed up for 1 to 15 years. The 1-, 2-, 5- and 10-year survival rate were 94.2% (121/129), 90.5% (116/129), 78.3% (101/129) and 17.8% (23/129) respectively. Conclusions: Partial penectomy is an appropriate and effective management for penile cancer. Lymph node metastasis is an important prognostic factor for penile cancer. We could significantly increase the survival rate of patients and reduce the complications by selecting reasonable inguinal lymphadenectomy timing.
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