Abstract：Objective: To assess the prognostic factors related to positive lymph nodes for renal cell carcinoma (RCC) with enlarged lymph nodes, since use of lymph node dissection in these patients was debatable. Methods: We retrospectively reviewed the clinicopathologic data of 328 patients with RCC who underwent radical nephrectomy (RN) and the enlarged lymph nodes were confirmed preoperatively or perioperatively. These patients were treated at the PLA General Hospital from January 2006 to December 2014. A multivariate logistic regression model was used to determine the clinicopathologic features of the primary tumor that were associated with positive regional lymph nodes at RN. Results: Younger age, distant metastasis, high nuclear grade, high tumor stage, and renal capsule invasion were significantly associated with positive lymph nodes in a multivariate setting. Conclusions: Younger age, distant metastasis, high nuclear grade, high tumor stage, and renal capsule invasion are the high risk factors for lymph node involvement at RN in RCC patients with enlarged lymph nodes.
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