Abstract：Objective: To improve the diagnosis and treatment of seminoma arising from cryptorchidism by summarizing the clinical features of this disease. Methods: Clinical data and prognostic information of 10 patients with seminoma arising from cryptorchidism admitted to Chinese PLA General Hospital from January 2000 to June 2014 were retrospectively analyzed. Results: Of the 10 patients, the average age was 38 years, the serological tumor markers alpha-fetoprotein (AFP) and human chorionic gonadotropin in beta subunit (β-HCG) were examined on all cases, and all of those patients were subjected to abdominal B ultrasound, 8 to abdominal CT, 1 to PET-CT, and 3 to puncture biopsy before operation. Nine cases were initially diagnosed as having abdominal mass. The tumor was located in the abdomen in 9 cases, and in the inguinal fold in one case. All cases were given surgery successfully, including 1 case of clinical stageⅠa, 5 cases of Ⅱb, 2 cases ofⅡc, 1 case of Ⅲa and 1 case of Ⅲc. Post-operative pathologically, there were 9 cases of pure seminoma, and 1 case of seminoma complicated with yolksac tumor. The 10 patients were followed up for 1.5 years to 15 years. Two patients were Lost follow-up, 7 patients had no recurrence and metastasis. In one case of recurrence 1.5 years after surgery, the recurrent tumor foci disappeared after 6 cycles of chemotherapy and 18 times of radiotherapy. Conclusions: Cryptorchidism is a risk factor of seminoma. Patients with seminoma arising from cryptorchidism will achieve satisfactory therapeutic effects after an aggressive surgical treatment supplemented with proper chemotherapy and radiotherapy.
[1]Mikuz G. Update on the pathology of testicular tumors. Anal Quant Cytopathol Histpathol, 2015,37(1):75-85. [2]Mannuel HD, Mitikiri N, Khan M, et al. Testicular germ cell tumors:biology and clinical update. Curr Opin Oncol, 2012,24(3):266-271. [3]Nallu A, Chimakurthi R, Hussain A, et al. Update on testicular germ cell tumors.Curr Opin Oncol, 2014,26(3):294-298. [4]Ferguson L, Agoulnik AI. Testicular cancer and cryptorchidism. Front Endocrinol (Lausanne), 2013,4:32. [5]Docimo SG, Silver RI, Cromie W. The undescended testicle: diagnosis and management. Am Fam Physician, 2000,62(9):2037-2044,2047-2048. [6]郭祥,刘红耀,马志方,等.隐睾固定术后睾丸恶变1例报告.中华男科学杂志,2012,18(1):76-77. [7]Banks K, Tuazon E, Berhane K, et al. Cryptorchidism and testicular germ cell tumors: comprehensive meta-analysis reveals that association between these conditions diminished over time and is modified by clinical characteristics. Front Endocrinol (Lausanne), 2012,3:182. [8]蔡冰,张奕雄,李湘斌.隐睾继发睾丸癌10例诊治分析.中华男科学杂志,2007,13(6):561-562. [9]张奕荣,蔡冰,李湘斌,等.隐睾恶变误诊(附4例报告).临床泌尿外科杂志,2007,22(8):610-611. [10]陈松,夏溟,严秋哲,等.隐睾继发睾丸癌的临床分析.中华泌尿外科杂志,2005,26(4):274-276. [11]Coursey Moreno C, Small WC, Camacho JC, et al. Testicular tumors:what radiologists need to know differential diagnosis, staging, and management. Radiographics, 2015,35(2):400-415. [12]Tomomasa H, Shimizu H, Sato S, et al. Clinical study of testicular germ cell tumors.Hinyokika Kiyo, 2001,47(6):389-395. [13]张朋,曾浩,卢一平,等.睾丸生殖细胞肿瘤176例临床诊治分析.中华男科学杂志,2006,12(3):237-239. [14]郑连文,李付彪,刘睿智,等.睾丸肿瘤87例临床分析.中华男科学杂志,2005,11(6):445-447.
