Effects of chemotherapy and embolization via bilateral internal iliac artery perfusion in patients with invasive bladder cancer on serum tumor-related indicators and 5-year survival rate
YU Yongjun1, ZHU Cunhai1, SHENG Bo1
1Department of Urology, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, Xiaogan 432000 China
Abstract：Objective： To analyze the clinical curative effect of transcatheter bilateral internal iliac arterial infusion chemotherapy plus embolization in the treatment of muscular invasive bladder cancer (MIBC), and the influence on levels of serum tumor-related indicators and 5-year survival rate. Methods: Seventy patients with MIBC admitted at our hospital during the period from September 2010 to May 2013 were treated by bladder preserving surgery. They were divided into group A and group B according to different methods for chemotherapy after operation. Thirty-six patients in group A were given transcatheter bilateral internal arterial infusion chemotherapy plus embolization, and 34 patients in group B were subjected to systemic chemotherapy. The adverse reactions during chemotherapy were observed and the short-term curative effect was evaluated. Serum samples were collected before and after treatment to detect the levels of tumor markers, and the 5-year survival of all patients was followed up. Results: There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05), and no serious adverse reactions occurred in both groups. The rank sum test showed that the short-term curative effect in group A was better than that in group B (P<0.05). Levels of serum soluble intercellular adhesion molecule-1 (sICAM-1), secreted protein (DKK), vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF) in both groups were significantly decreased after treatment, and the decrease was greater in group A than in group B (P<0.05). The 5-year cumulative survival rate in group A was slightly higher than that in the group A (63.88% vs. 52.94%, P>0.05). Conclusion: Transcatheter bilateral internal iliac arterial infusion chemotherapy plus embolization can improve the clinical curative effect on MIBC, and decrease the levels of serum tumor markers DKK, VEGF, FGF and MMPs in patients. It is expected to improve the prognosis.
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