Treatment of complex renal tumors with partial nephrectomy: current status and progress
Wang qiang1, 2 Zhang Xu1
1Department of Urology, Chinese PLA General Hospital, Beijing 100853, China; 2Department of Urology, Organ Transplant Institute of 309th Hospital of PLA
Abstract:The incidence of renal cell carcinoma is gradually increased in China, and it has become a kind of tumors with the 10th cancer incidence in men at 2008. Complex renal tumors are defined as a kind of localized tumors with such clinical and biological characteristics as RENAL score ≥7, anatomic or functional solitary kidney, and without local or remote metastasis. Partial nephrectomy (PN) for the complex renal tumors is great challenges for the urology surgery. Recently, some important progresses have been made on the operational therapy of complex renal tumors, along with the developments on the surgery techniques, equipments, and ancillaries. RN surgeries such as open PN, laparoscopic PN, and robot-assisted PN, have gradually replaced radical nephrectomy, and have effectively improved the quality of life and overall survival of patients. In this paper, progress on the methods, safety, and effectiveness in the PN treatment of complex renal tumors was reviewed.
王强 张旭. 肾部分切除术治疗复杂性肾肿瘤的研究现状及进展[J]. 微创泌尿外科杂志, 2016, 5(5): 314-320.
Wang qiang Zhang Xu. Treatment of complex renal tumors with partial nephrectomy: current status and progress. JOURNAL OF MINIMALLY INVASIVE UROLOGY, 2016, 5(5): 314-320.
[1]Ljungberg B, Bensalah K, Canfield S, et al. EAU guidelines on renal cell carcinoma: 2014 update. Eur Urol, 2015,67(5):913-924. [2]Siegel R, Naishadham D, Jemal A, et al. Cancer statistics, 2013. CA Cancer J Clin, 2013, 63(1):11-30. [3]那彦群,叶章群,孙颖浩,等.中国泌尿外科疾病诊断治疗指南(2014版).北京:人民卫生出版社,2014:184-185. [4]Kim SP, Murad MH, Thompson RH, et al. Comparative effectiveness for survival and renal function of partial and radical nephrectomy for localized renal tumors: a systematic review and meta-analysis. J Urol, 2012, 188(1):51-57. [5]Klein FA, Gash JR, Ward E, et al. Diagnosis and staging of renal cell carcinoma. In: Richie JR, D'Amico AV (eds.), Urologic Oncology. Philadelphia, Elsevier Sanders, 2005:173-194. [6]Crépel M, Jeldres C, Perrotte P, et al. Nephron-sparing surgery is equally effective to radical nephrectomy for T1BN0M0 renal cell carcinoma: a population-based assessment. Urology, 2010,75(2):271-275. [7]Simmons MN, Weight CJ, Gill IS. Laparoscopic radical versus partial nephrectomy for tumors >4 cm: intermediate- term oncologic and functional outcomes. Urology, 2009, 73(5):1077-1082. [8]Medina-Polo J, Romero-Otero J, Rodríguez-Antolín A, et al. Can partial nephrectomy preserve renal function and modify survival in comparison with radical nephrectomy ? Scand J Urol Nephrol, 2011, 45(2):143-150. [9]Weight CJ, Lieser G, Larson BT, et al. Partial nephrectomy is associated with improved overall survival compared to radical nephrectomy in patients with unanticipated benign renal tumours. Euro Urol, 2010,58(2):293-298. [10]Weight CJ, Larson BT, Fergany AF, et al. Nephrectomy induced chronic renal insufficiency is associated with increased risk of cardiovascular death and death from any cause in patients with localized cT1b renal masses. J Urol, 2010,183(4):1317-1323. [11]Tan HJ, Norton EC, Ye ZJ, et al. Long-term survival following partial versus radical nephrectomy among older patients with early-stage kidney cancer. JAMA, 2012,307(15):345-356. [12]Singer EA, Bratslavsky G. Management of locally recurrent kidney cancer. Cur Urol Rep, 2010,11(1):15-21. [13]Bensalah K, Pantuck AJ, Rioux-Leclercq N, et al. Positive surgical margin appears to have negligible impact on survival of renal cell carcinomas treated by nephron-sparing surgery. Eur Urol, 2010, 57(3):466-473. [14]Bernhard JC, Pantuck AJ, Wallerand H, et al. Predictive factors for ipsilateral recurrence after nephron-sparing surgery in renal cell carcinoma. Eur Urol, 2010,57(6):1080-1086. [15]Russo P, Huang W. The medical and oncological rationale for partial nephrectomy for the treatment of T1 renal cortical tumors. Urol Clin North Amer, 2008,35(4):635-643. [16]Huang WC, Levey AS, Serio AM, et al. Chronic kidney disease after nephrectomy in patients with renal cortical tumours: a retrospective cohort study. Lancet Oncol, 2006,7(9):735-740. [17]Huang WC, Elkin EB, Levey AS, et al. Partial nephrectomy versus radical nephrectomy in patients with small renal tumors—is there a difference in mortality and cardiovascular outcomes ? J Urol, 2009, 181(1):55-62. [18]Klarenbach S, Moore RB, Chapman DW, et al. Adverse renal outcomes in subjects undergoing nephrectomy for renal tumors: a population-based analysis. Eur Urol, 2011,59(3): 333-339. [19]Serni S, Vittori G, Frizzi J, et al. Simple enucleation for the treatment of highly complex renal tumors: Perioperative, functional and oncological results. EJSO, 2015,41(7):934-940. [20]Wang H, Sun LA, Wang YW, et al. Mini-flank supra-12th rib incision for open partial nephrectomy for renal tumor with renal nephrometry score ≥10. An innovation of traditional open surgery. Medicine, 2015,94(13):1-6.[21]Lucas SM, Mellon MJ, Erntsberger L, et al. A comparison of robotic, laparoscopic and open partial nephrectomy. J Soc Laparoendo Surg, 2012,16(4):581-587. [22]Campbell SC, Novick AC, Streem SB, et al. Complications of nephron sparing surgery for renal tumors. J Urol, 1994,151(5):1177-1180. [23]张雪培, 任选义. 复杂性肾脏肿瘤开放手术保留肾单位的技术探讨. 现代泌尿外科杂志, 2015, 3(3):141-143. [24]Turna B, Aron M, Gill IS. Expanding indications for laparoscopic partial nephrectomy. Urology, 2008,72(3):481-487. [25]El-Ghazaly TH, Mason RJ, Rendon RA. Oncological outcomes of partial nephrectomy for tumours larger than 4 cm: A systematic review. Can Urol Assoc J, 2014,8(1-2):61-66. [26]Bratslavsky G, Linehan WM. Long-term management of bilateral, multifocal, recurrent renal carcinoma. Nat Rev Urol, 2010, 7(5):267-275. [27]Steinberg AP, Kilciler M, Abreu SC, et al. Laparoscopic nephron-sparing surgery for two or more ipsilateral renal tumors. Urology, 2004, 64(2):255-258. [28]Gill IS, Colombo JR, Frank I, et al. Laparoscopic partial nephrectomy for hilar tumors. J Urol, 2005,174(3):850-853. [29]蒲小勇,徐战平,刘久敏,等.两种入路腹腔镜下肾部分切除术治疗R.E.N.A.L.评分≥7 的肾肿瘤的比较研究. J South Med Univ, 2014, 34(12):1818-1821. [30]张东旭,滕竞飞,李勋钢,等.后腹腔镜下肾部分切除术在R.E.N.A.L.评分为中度复杂性肾癌中的应用.临床泌尿外科杂志,2012,27(10):737-740. [31]Gill IS, Colombo JR, Moinzadeh A, et al. Laparoscopic partial nephrectomy in solitary kidney. J Urol, 2006,175(2): 454-458. [32]Ramani AP, Desai MM, Steinberg AP, et al. Complications of laparoscopic partial nephrectomy in 200 cases. J Urol, 2005,173(1):42-47. [33]张旭,高江平,符伟军,等.机器人辅助腹腔镜在泌尿外科手术中的临床应用(附500例报告).微创泌尿外科杂志,2014,3(1):4-7. [34]Gupta GN, Boris R, Chung P, et al. Robot-assisted laparoscopic partial nephrectomy for tumors greater than 4 cm and high nephrometry score: feasibility, renal functional, and oncological outcomes with minimum 1 year follow-up. Urol Oncol, 2013,31(1):51-56. [35]Shiroki R, Fukami N, Fukaya K, et al. Robot-assisted partial nephrectomy: Superiority over laparoscopic partial nephrectomy. Int J Urol, 2016,23(2):122-131. [36] Jang HJ, Song W, Suh YS, et al. Comparison of perioperative outcomes of robotic versus laparoscopic partial nephrectomy for complex renal tumors (RENAL nephrometry score of 7 or higher). Korean J Urol, 2014,55(12):808-813. [37]Ficarra V, Rossanese M, Gnech M, et al. Outcomes and limitations of laparoscopic and robotic partial nephrectomy. Curr Opin Urol, 2014,24(5):441-447. [38]Long JA, Yakoubi R, Lee B, et al. Robotic versus laparoscopic partial nephrectomy for complex tumors: comparison of perioperative outcomes. Eur Urol, 2012, 61(6):1257-1262. [39]Choi JE, You JH, Kim DK, et al. Comparison of perioperative outcomes between robotic and laparoscopic partial nephrectomy: a systematic review and meta-analysis. Eur Urol, 2015,67(5):891-901. [40]Volpe A, Garrou D, Amparore D, et al. Perioperative and renal functional outcomes of elective robot-assisted partial nephrectomy (RAPN) for renal tumours with high surgical complexity. BJU Int, 2014,114(6):903-909. [41]Eyraud R, Long JA, Snow-Lisy D, et al. Robot-assisted partial nephrectomy for hilar tumors: perioperative outcomes. Urology, 2013,81(6):1246-1251. [42]Hillyer SP, Bhayani SB, Allaf ME, et al. Robotic partial nephrectomy for solitary kidney: a multi-institutional analysis. Urology, 2013,81(1):93-97. [43]Abreu AL, Berger AK, Aron M, et al. Minimally invasive partial nephrectomy for single versus multiple renal tumors. J Urol, 2013,189(2):462-467. [44]Autorino R, Khalifeh A, Laydner H, et al. Robot-assisted partial nephrectomy (RAPN) for completely endophytic renal masses: a single institution experience. BJU Int, 2014,113(5):762-768. [45]叶华茂,王蓉,吴震杰,等.机器人辅助腹腔镜肾部分切除术治疗PADUA评分≥10分的肾脏肿瘤.第二军医大学学报,2014,35(7):800-803. [46]Wang YB, Ma X, Huang QB, et al. Comparison of robot-assisted and laparoscopic partial nephrectomy for complex renal tumours with a RENAL nephrometry score ≥7: peri-operative and oncological outcomes. BJU Int, 2016,117(1):126-130. [47]Benway BM, Bhayani SB, Rogers CG, et al. Robot assisted partial nephrectomy versus laparoscopic partial nephrectomy for renal tumors: a multi-institutional analysis of perioperative outcomes. J Urol, 2009,182(3):866-872. [48]Ukimura O, Gill IS. Image-fusion, augmented reality, and predictive surgical navigation. Urol Clin North Am, 2009,36(2):115-123. [49]Hyams ES, Perlmutter M, Stifelman MD. A prospective evaluation of the utility of laparoscopic Doppler technology during minimally invasive partial nephrectomy. Urology, 2011,77(3):617-620. [50]Ukimura O. Image-guided surgery in minimally invasive urology. Cur Opin Urol, 2010, 20(2):136-140. [51]尚吉文,张旭,马鑫,等.倒刺缝合在腹腔镜下肾部分切除术治疗复杂性肾肿瘤中的应用.中华泌尿外科杂志,2013,34(12):929-932. [52]马鑫,李宏召,张旭,等.后腹腔镜肾部分切除术中免打结分层缝合法修补肾脏组织缺损的临床应用研究. 临床泌尿外科杂志,2012,27(2):81-83. [53]瓦斯里江·瓦哈甫,李宏召,张旭,等.后腹腔镜肾部分切除术两种不同缝合方式的安全性和预后比较. 微创泌尿外科杂志,2012,1(1):59-63. [54]Orvieto MA, Chien G, Laven B, et al. Eliminating knot tying during warm ischemia time for laparoscopic partial nephrectomy. J Urol, 2004,172(6 Pt 1):2292-2295. [55]Pruthi RS, Chun J, Richman M. The use of a fibrin tissue sealant during laparoscopic partial nephrectomy. BJU Int, 2004,93(6):813-817. [56]Gill IS, Ramani AP, Spaliviero M, et al. Improved homeostasis during laparoscopic partial nephrectomy using gelatin matrix thrombin sealant. Urology, 2005,65(3):463-466. [57]Hidas G, Kastin A, Mullerad M, et al. Sutureless nephron-sparing surgery: use of albumin glutaraldehyde tissue adhesive (BioGlue). Urology, 2006,67(4):697-700. [58]Thompson RH, Lane BR, Lohse CM, et al. Every minute counts when the renal hilum is clamped during partial nephrectomy. Eur Urol, 2010,58(3):340-345. [59]俞鸿凯,马鑫,李宏召,等.一种新的肾门前后唇巨大肾门肿瘤的肾部分切除术外科技术及其局部解剖学原理(附18例报告). 微创泌尿外科杂志, 2015, 4(3):163-166. [60]Benway BM, Wang AJ, Cabello JM, et al. Robotic partial nephrectomy with sliding-clip renorrhaphy: technique and outcomes. Eur Urol, 2009,55(3):592-599. [61]Gill IS, Kamoi K, Aron M, et al. 800 Laparoscopic partial nephrectomies: a single surgeon series. J Urol, 2010,183(1):34-41. [62]San Francisco IF, Sweeney MC, Wagner AA. Robot-assisted partial nephrectomy: early unclamping technique. J Endourol, 2011,25(2):305-308. [63]Viprakasit DP, Altamar HO, Miller NL, et al. Selective renal parenchymal clamping in robotic partial nephrectomy: initial experience. Urology, 2010,76(3):750-753. [64]Gill IS, Eisenberg MS, Aron M, et al. 'Zero ischemia' partial nephrectomy: novel laparoscopic and robotic technique. Eur Urol, 2011,59(1):128-34. [65]刘新,马鑫,张旭.低温技术在腹腔镜肾部分切除术中的应用.微创泌尿外科杂志,2014,3(2):125-128.