Li Lin1, Li Aolin2, Wang Pu1, Yue Shuhua1, Yao Lin2,*
1Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China; 2Department of Urology, Peking University First Hospital, Beijing 100034, China
Abstract：Recently, photoacoustic imaging （PAI） has been emerging as an unique noninvasive biomedical imaging tool with strong molecular selectivity and deep tissue penetration. Photoacoustic imaging provides endogenous and exogenous contrast, and this feature greatly promoted its clinical development. Abnormal chemical accumulation in tumors of urinary system can be detected by photoacoustic imaging. Combined with intelligent methods, such as spectral analysis and deep learning, photoacoustic imaging can realize localization, diagnosis, preoperative staging of tumor. This article introduces the photoacoustic imaging and summarizes the application of photoacoustic imaging in urology.
李琳, 李傲林, 王璞, 岳蜀华, 姚林. 光声成像技术在泌尿外科的应用[J]. 微创泌尿外科杂志, 2022, 11(5): 327-332.
Li Lin, Li Aolin, Wang Pu, Yue Shuhua, Yao Lin. Application of photoacoustic imaging in urology. JOURNAL OF MINIMALLY INVASIVE UROLOGY, 2022, 11(5): 327-332.
[1] Zheng RS, Zhang S, Zeng HM, et al.Cancer incidence and mortality in China, 2016[J]. J Nat Cancer Center, 2022, 2(1): 1-9. [2] Bedard N, Pierce M, El-Naggar A, et al.Emerging roles for multimodal optical imaging in early cancer detection: a global challenge[J]. Technol Cancer Res Treat, 2010, 9(2): 211-217. [3] Yang C, Lan H, Gao F, et al.Review of deep learning for photoacoustic imaging[J]. Photoacoustics, 2021, 21: 100215. [4] Hauptmann A, Cox BT.Deep learning in photoacoustic tomography: current approaches and future directions[J]. J Biomed Optics, 2020, 25(11): 112903. [5] Gröhl J, Schellenberg M, Dreher K, et al.Deep learning for biomedical photoacoustic imaging: a review[J]. Photoacoustics, 2021, 22: 100241. [6] Bell AG. Upon the production and reproduction of sound by light[J]. Am J Sci, 1880, 20: 404-426. [7] Xia J, Yao J, Wang LV.Photoacoustic tomography: principles and advances[J]. Electromagnetic Waves (Cambridge, Mass), 2014, 147: 1-22. [8] Attia ABE, Balasundaram G, Moothanchery M, et al.A review of clinical photoacoustic imaging: current and future trends[J]. Photoacoustics, 2019, 16: 100144. [9] Beard P.Biomedical photoacoustic imaging[J]. Interface Focus, 2011, 1(4): 602-631. [10] 徐晓辉, 李辉. 生物医学光声成像[J]. 物理学和高声技术, 2008, 37(2): 111-118. [11] Wang HW, Chai N, Wang P, et al.Label-free bond-selective imaging by listening to vibrationally excited molecules[J]. Phys Rev Lett, 2011, 106(23): 238106. [12] Lediju Bell MA.Photoacoustic imaging for surgical guidance: principles, applications, and outlook[J]. J Appl Phys, 2020, 128(6): 060904. [13] Zemp RJ. Photoacoustic imaging in biomedicine[C]. Baltimore: Optica Publishing Group, 2011. [14] Wang P, Wang HW, Wang JX, et al.Hyperspectral vibrational photoacoustic imaging of lipids and collagen[C]. SPIE Photons Plus Ultrasound: Imaging and Sensing, 2012,82231I. [15] Allen TJ, Beard PC, Hall A, et al.Spectroscopic photoacoustic imaging of lipid-rich plaques in the human aorta in the 740 to 1400 nm wavelength range[J]. J Biomed Opt, 2012, 17(6): 061209. [16] Wang B, Karpiouk A, Yeager D, et al.Intravascular photoacoustic imaging of lipid in atherosclerotic plaques in the presence of luminal blood[J]. Optics Letters, 2012, 37(7): 1244-1246. [17] Zhang HF, Maslov K, Stoica G, et al.Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging[J]. Nat Biotechnol, 2006, 24(7): 848-851. [18] Wang LV, Yao J.A practical guide to photoacoustic tomography in the life sciences[J]. Nat Methods, 2016, 13(8): 627-638. [19] Wang LV, Hu S.Photoacoustic tomography: In vivo imaging from organelles to organs[J]. Science, 2012, 335(6075): 1458-1462. [20] Jo J, Tian C, Xu G, et al.Photoacoustic tomography for human musculoskeletal imaging and inflammatory arthritis detection[J]. Photoacoustics, 2018, 12: 82-89. [21] Bungart BL, Lan L, Wang P, et al.Photoacoustic tomography of intact human prostates and vascular texture analysis identify prostate cancer biopsy targets[J]. Photoacoustics, 2018, 11: 46-55. [22] Valluru KS, Chinni BK, Rao NA, et al.Development of a c-scan photoacoutsic imaging probe for prostate cancer detection[C]. SPIE Photons Plus Ultrasound: Imaging and Sensing, 2011, 7968(11): 215. [23] Chen Y, Xu C, Zhang Z, et al.Prostate cancer identification via photoacoustic spectroscopy and machine learning[J]. Photoacoustics, 2021, 23: 100280. [24] Sivasubramanian K, Periyasamy V, Dienzo RA, et al.Hand‐held, clinical dual mode ultrasound‐photoacoustic imaging of rat urinary bladder and its applications[J]. J Biophotonics, 2018, 11(5): e201700317. [25] Orlova A, Sirotkina M, Smolina E, et al.Raster-scan optoacoustic angiography of blood vessel development in colon cancer models[J]. Photoacoustics, 2019, 13: 25-32. [26] Chen Z, Rank E, Meiburger KM, et al.Non-invasive multimodal optical coherence and photoacoustic tomography for human skin imaging[J]. Sci Rep, 2017, 7(1): 1-11. [27] Menezes GLG, Pijnappel RM, Meeuwis C, et al.Downgrading of breast masses suspicious for cancer by using optoacoustic breast imaging[J]. Radiology, 2018, 288(2): 355-365. [28] Kwon EO, Carver BS, Snyder ME, et al.Impact of positive surgical margins in patients undergoing partial nephrectomy for renal cortical tumors[J]. BJU Int, 2007, 99(2): 286-289. [29] Van Poppel H, Joniau S.How important are surgical margins in nephron-sparing surgery?[J]. Euro Urol Suppl, 2007, 6(8): 533-539. [30] Kubinski DJ, Clark P E, Assimos DG, et al.Utility of frozen section analysis of resection margins during partial nephrectomy[J]. Urology, 2004, 64(1): 31-34. [31] Alharbi FM, Chahwan CK, Le Gal SG, et al.Intraoperative ultrasound control of surgical margins during partial nephrectomy[J]. Urol Ann, 2016, 8(4): 430-433. [32] Qin B, Hu H, Lu Y, et al.Intraoperative ultrasonography in laparoscopic partial nephrectomy for intrarenal tumors[J]. PLoS One, 2018, 13(4): e0195911. [33] Parekh DJ, Lin WC, Herrell SD.Optical spectroscopy characteristics can differentiate benign and malignant renal tissues: a potentially useful modality[J]. J Urol, 2005, 174(5): 1754-1758. [34] Bensalah K, Fleureau J, Rolland D, et al.Raman spectroscopy: a novel experimental approach to evaluating renal tumours[J]. Eur Urol, 2010, 58(4): 602-608. [35] Wang M, Tulman DB, Sholl AB, et al.Partial nephrectomy margin imaging using structured illumination microscopy[J]. J Biophotonics, 2018, 11(3): e201600328. [36] Li L, Wu H, Hu S, et al.Clear cell renal cell carcinoma detection by multimodal photoacoustic tomography[J]. Photoacoustics, 2021, 21: 100221. [37] Welch HG, Schwartz LM, Woloshin S.Prostate-specific antigen levels in the United States: implications of various definitions for abnormal[J]. J Natl Cancer Inst, 2005, 97(15): 1132-1137. [38] Flanigan RC, Catalona WJ, Richie JP, et al.Accuracy of digital rectal examination and transrectal ultrasonography in localizing prostate cancer[J]. J Urol, 1994, 152(5): 1506-1509. [39] Harvey C, Pilcher J, Richenberg J, et al.Applications of transrectal ultrasound in prostate cancer[J]. Br J Radiol, 2012, 85(special_issue_1): S3-S17. [40] Ellis WJ, Brawer MK.The significance of isoechoic prostatic carcinoma[J]. J Urol, 1994, 152(6): 2304-2307. [41] Ganie FA, Wanie MS, Ganie SA, et al.Correlation of transrectal ultrasonographic findings with histo pathology in prostatic cancer[J]. J Educ Health Promot, 2014 ,3:38. [42] Chen ME, Troncoso P, Johnston DA, et al.Optimization of prostate biopsy strategy using computer based analysis[J]. J Urol, 1997, 158(6): 2168-2175. [43] 崔超超, 张景良, 焦建华, 等. MRI 与 PET/CT 在前列腺穿刺活检中的应用[J]. 微创泌尿外科杂志, 11(2): 134-138. [44] El-Gohary SH, Metwally MK, Eom S, et al.Design study on photoacoustic probe to detect prostate cancer using 3D Monte Carlo simulation and finite element method[J]. Biomed Eng Lett, 2014, 4(3): 250-257. [45] Kothapalli SR, Sonn GA, Choe JW, et al. Simultaneous transrectal ultrasound and photoacoustic human prostate imaging[J]. Sci Transl Med, 2019 ,11(507):eaav2169. [46] Yaseen MA, Ermilov SA, Brecht HPF, et al.Optoacoustic imaging of the prostate: development toward image-guided biopsy[J]. J Biomed Opt, 2010, 15(2): 021310. [47] Ishihara M, Shinchi M, Horiguchi A, et al.Possibility of transrectal photoacoustic imaging-guided biopsy for detection of prostate cancer[C]. SPIE Photons Plus Ultrasound: Imaging and Sensing, 2017. [48] Horiguchi A, Shinchi M, Nakamura A, et al.Pilot study of prostate cancer angiogenesis imaging using a photoacoustic imaging system[J]. Urology, 2017, 108: 212-219. [49] Wang X, Roberts WW, Carson PL, et al. Photoacoustic tomography: a potential new tool for prostate cancer[J]. Biomed Opt Express, 2010, 1(4): 1117-1126. [50] Cong B, Qiu C, Ren YG, et al.A low cost sensitive transrectal photoacoustic probe with single-fiber bright-field illumination for in vivo canine prostate imaging and real-time biopsy needle guidance[J]. IEEE Sensors J, 2020, 20(18): 10974-10980. [51] Kumon RE, Deng CX, Wang XD.Frequency-domain analysis of photoacoustic imaging data from prostate adenocarcinoma tumors in a murine model[J].Ultrasound Med Biol, 2011, 37(5):834-839. [52] Kamaya A, Vaithilingam S, Chung BI, et al.Photoacoustic imaging of the bladder: a pilot study[J]. J Ultra Med, 2013, 32(7): 1245-1250. [53] Kim K, Youm JY, Lee EH, et al.Tapered catheter-based transurethral photoacoustic and ultrasonic endoscopy of the urinary system[J]. Opt Express, 2022, 30(15): 26169-26181. [54] Xie Z, Roberts W, Carson P, et al.Evaluation of bladder microvasculature with high-resolution photoacoustic imaging[J]. Opt Lett, 2011, 36(24): 4815-4817. [55] Nguyen VP, Oh J, Park S, et al.Feasibility of photoacoustic evaluations on dual-thermal treatment of ex vivo bladder tumors[J]. J Biophotonics, 2017, 10(4): 577-588.
