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微创泌尿外科杂志  2014, Vol. 3 Issue (5): 259-262    
  论著 本期目录 | 过刊浏览 | 高级检索 |
76例肾嫌色细胞癌的临床诊治分析
顾良友1,马鑫1,李宏召1,沈东来1,高宇1,范阳1,李新涛1,张旭1
1中国人民解放军总医院泌尿外科 中国人民解放军总医院肾脏疾病国家重点实验室 100853 北京
The clinical analysis of 76 patients with chromophobe renal cell carcinoma
Gu Liangyou1,Ma Xin1,Li Hongzhao1,Shen Donglai1,Gao Yu1,Fan Yang1,Li Xintao1,Zhang Xu1
1Department of Urology/State Key Laboratory of Kideny Dieases, Chinese PLA General Hospital, Beijing 100853,China
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摘要 目的:分析总结肾嫌色细胞癌的临床特点,提高其临床诊治水平。方法:回顾性分析2010年1月~2013年7月期间收治的76例病理诊断为肾嫌色细胞癌患者的临床及病理资料。其中男40例,女36例,年龄22~71岁,平均49岁。病变位于左侧37例,右侧39例。结果:76例均行手术治疗,其中根治性肾切除术47例,保留肾单位手术29例。73例行腹腔镜手术,3例行开放手术治疗,两组手术时间差异无统计学意义,但腹腔镜组平均术中出血量明显低于开放手术组。肿瘤最大径为1~11 cm,平均4.6 cm。病理分期:64例pT1N0M0,10例pT2N0M0,1例pT3N0M0,1例pT1N0M1。Fuhrman分级:Ⅰ级 50例,Ⅱ级 16例,Ⅲ级 6例,Ⅳ级 4例。术后76例均获得随访,随访时间15~58个月,平均(33.8±12.0)个月,未出现复发或因肿瘤导致死亡者。结论:肾嫌色细胞癌是肾细胞癌的一种少见类型,手术切除是目前首选的治疗方式,腹腔镜手术与开放手术治疗效果相似,微创优势显著。本病较少复发和转移,预后良好。
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顾良友
马鑫
李宏召
沈东来
高宇
范阳
李新涛
张旭
关键词 肾细胞癌肾嫌色细胞癌诊断治疗预后    
AbstractObjective: To improve the diagnosis and treatment of chromophobe renal cell carcinoma (CRCC), we investigated the clinical features of CRCC patients in our hospital. Methods: We retrospectively reviewed the clinicopathologic data of 76 patients with CRCC seen in our hospital from January 2010 to July 2013. The mean age of these patients at diagnosis was 49 years-old, including 40 males and 36 females. All tumors were localized unilaterally, with 37 in left kidney and 39 in right kidney. Results: All of the 76 patients successfully received nephrectomy. Forty-seven patients underwent radical nephrectomy, 29 patients received nephron sparing surgery. Seventy-three patients were treated with laparoscopic surgery and 3 were treated with open surgery, with the similar mean operative time. The mean operative blood loss was significantly less in laparoscopic surgery group. The average maximum diameter of tumors was 4.6 cm. Among them, 64 patients were at pT1N0M0, 10 at pT2N0M0, 1 at pT3N0M0and 1 at pT1N0M1. The pathologic Fuhrman grade of CRCC was G1 in 50 cases, G2 in 16 cases, G3 in 6 cases, G4 in 4 cases. All patients were followed up with a mean duration of 33.8 months and no local recurrence was found. Conclusions: CRCC is a rare subtype of renal cell carcinoma with infrequent recurrence and metastasis. Surgery is the standard treatment for CRCC. The laparoscopic surgery has similar treatment efficacy to open surgery, but deserves significant micro-invasive advantages. CRCC patients have favorable prognosis.
Key wordsrenal cell carcinoma    chromophobe renal cell carcinoma    diagnosis    treatment    prognosis
收稿日期: 2014-09-20     
ZTFLH:  R737.11  
基金资助:国家高新技术研究发展计划(863计划)(2012AA02101)
通讯作者: 张旭,xzhang@foxmail.com   
引用本文:   
顾良友,马鑫,李宏召,沈东来,高宇,范阳,李新涛,张旭. 76例肾嫌色细胞癌的临床诊治分析[J]. 微创泌尿外科杂志, 2014, 3(5): 259-262.
Gu Liangyou,Ma Xin,Li Hongzhao,Shen Donglai,Gao Yu,Fan Yang,Li Xintao,Zhang Xu. The clinical analysis of 76 patients with chromophobe renal cell carcinoma. JOURNAL OF MINIMALLY INVASIVE UROLOGY, 2014, 3(5): 259-262.
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