Abstract：Objective: To evaluate the efficacy and safety of external physical vibration lithecbole （EPVL）in assistant treatment of residual stones after ESWL/RIRS by meta-analysis, and to explorethe best operation time. Methods: Several online databases including Pubmed, Embase, Cochrane Library, CNKI, VIP, CBM and Wanfang were searched to collect the clinical randomized controlled trials （RCTs） comparing EPVL with the conventional treatmentafter ESWL/RIRS. The data were screened and extracted by two independent reviewers respectively, and the quality of the included articles was evaluated with the Cochrane Collaboration's tool for assessing risk of bias. Then the meta-analysis was conducted with the software of Revman 5.3. Results: 7 RCTs were obtained with 946 cases including the treatment group （n =463） and the control group （n = 483）. The results of meta-analysis showed that the stone-free rate （SFR） ofthe treatment group was significantly higher than that of the control group at each period after lithotripsy. In RIRS subgroup, 3-5 weeks after lithotripsy, the positive rate of urinary leukocyte and hematuria in the treatment group were significantly lower than those in the control group. Conclusion: EPVL is used to assist the removal of stones after ESWL/RIRS, which can significantly improve the SFR and reduce postoperative complications. In order to obtain higher SFR, reduce postoperative complications and avoid excessive medical treatment, we recommend that one week after ESWL/RIRS, EPVL should be used to treat the patients according to the stone excretion.
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