Abstract:Objective: To investigate the clinical manifestations, pathological features, diagnosis, treatment and prognosis of reninoma. Methods: A retrospective analysis of the clinical data of 1 case of reninoma treated in our department in 2017 was made, and the clinical manifestations, diagnosis, treatment and prognosis of reninoma in combination were summarized with related literature. Results: The patient underwent laparoscopic partial right nephrectomy without antihypertensive drugs. The blood pressure was maintained at 110/70 mmHg. Postoperative pathological examination showed paraglomerular cell tumors, immunohistochemistry revealed CD34 (+), SMA (-), NSE (-), CD10 (-), PAX-8 (-), the blood pressure and the plasma renin levels were normal after 3 months. No recurrence of the tumors was observed on CT. Conclusions: Reninoma is a rare renal cortical benign tumor characterized by the secretion of large amounts of renin and secondary hypertension. However, because of the low incidence of the disease, it is easily misdiagnosed. Confirmation of the diagnosis should be based on clinical manifestations, imaging data and pathological features, and laparoscopic partial nephrectomy is an effective method for the treatment of renin tumors.
李宁, 栾婷, 王海峰, 左毅刚, 王剑松. 肾素瘤1例报告并文献分析[J]. 微创泌尿外科杂志, 2019, 8(2): 137-140.
LI Ning, LUAN Ting, WANG Haifeng, ZUO Yigang, WANG Jiansong. One case report of reninoma and literature analysis. JOURNAL OF MINIMALLY INVASIVE UROLOGY, 2019, 8(2): 137-140.
[1] VIDAL-PETIOT E, BENS M, CHOUDAT L, et al.A case report of reninoma: radiological and pathological features of the tumour and characterization of tumour-derived juxtaglomerular cells in culture. J Hypertens, 2015,33(8):1709-1715.
[2] ROBERTSON PW, KLIDJIAN A, HARDING LK, et al.Hypertension due to a renin-secreting renal tumour. Am J Med, 1967,43(6):963-976.
[3] 王宽,左晓晓,王朝明,等.肾素瘤2例报告并文献复习.中国医学工程,2017,25(6):57-60.
[4] OEI L, VAN DEN MEIRACKER AH, OEI EH,et al. Reninoma: A Rare Cause of Curable Hypertension and Hypokalemia. Am J Med, 2016,129(8):e131-e132.
[5] ROSEI CA, GIACOMELLI L, SALVETTI MA, et al.Advantages of renin inhibition in a patient with reninoma. Int J Cardiol, 2015,187:240-242.
[6] WONGA L, HSU TH, PERLROTH MG, et al.Reninoma: case report and literature review. J Hypertens, 2008,26(2):368-373.
[7] DONG D, LI H, YAN W, et al.Juxtaglomerular cell tumor of the kidney--a new classification scheme. Urol Oncol, 2010,28(1):34-38.
[8] KIM MJ, KIM JH, Kim IY, et al.Reninoma masked by the use of an angiotensin receptor blocker. Iran J Kidney Dis, 2016,10(6):413-415.
[9] OSAWA S, HOSOKAWA Y, SODA T, et al.Juxtaglomerular cell tumor that was preoperatively diagnosed using selective renal venous sampling. Intern Med, 2013,52(17):1937-1942.
[10] XUE M, CHEN Y, ZHANG J, et al.Reninoma coexisting with adrenal adenoma during pregnancy: A case report. Oncol Lett, 2017,13(5):3186-3190.
[11] 徐维锋,李汉忠,肖河,等.肾素瘤的诊断及外科处理.中华泌尿外科杂志,2008,29(7):450-454.
[12] KARAOSMANOGLU AD, ONUR MR, SHIRKHODA AA, et al.Unusual benign solid neoplasms of the kidney: cross-sectional imaging findings. Diagn Interv Radiol, 2015,21(5):376-381.
[13] 董方,商建峰,贺晨宇,等.肾素瘤1例并文献复习.临床与实验病理学杂志,2018,34(7):787-789.
[14] XU B, ZHANG Q, JIN J.Hypertension secondary to reninoma treated with laparoscopic nephron-sparing surgery in a child. Urology, 2012,80(1):210-213.
[15] DUAN X, BRUNEVAL P, HAMMADEH R, et al.Metastatic juxtaglomerular cell tumor in a 52-year-old man. Am J Surg Pathol, 2004,28(8):1098-1102.