Abstract：Objective: To investigate the relationship between preoperative neutrophil to lymphocyte ratio (NLR) and prognosis in non-muscle invasive bladder cancer (NMIBC) patients undergoing transurethral resection of bladder tumor (TURBT). Methods: We retrospectively collected data of 472 eligible patients who were diagnosed as having NMIBC and received TURBT between January 2003 and December 2011. The association of NLR with clinicopathological characteristics was further analyzed by dichotomizing our sample into those with NLR ≤ 2.32 (low NLR group) and those with NLR>2.32 (high NLR group), based on the receiver operating characteristic curve (ROC) analysis. Overall survival (OS) and cancer specific survival (CSS) were estimated by Kaplan-Meier analysis, and the log-rank test was used to compare differences between groups. Univariate and multivariate Cox regression analyses were plotted to assess the prognostic value of NLR in NMIBC patients. Results: The median OS was 82.0 months in the low NLR group, and 67.0 months in the high NLR group (OS: P=0.004). Kaplan-Meier survival analysis revealed that lower NLR was significantly correlated with greater OS and greater CSS.NLR was shown to be an independent predictor for OS (hazard ratio [HR], 1.877; 95% confidence interval [CI], 1.363-2.583; P<0.001) and CSS (hazard ratio [HR], 13.820; 95% confidence interval [CI], 3.45 to 60.730; P<0.001). Conclusions: NLR ≤ 2.32 was independently associated with greater OS and CSS in patients with NMIBC undergoing TURBT and may serve as a valuable prognostic factor for the therapeutic decision making.
王巨昆, 尚振华, 崔波, 王旭, 颜灏, 王琦, 崔昕, 李进, 贾春松, 欧彤文. 术前中性粒细胞与淋巴细胞比值对非肌层浸润性膀胱癌患者预后的评估价值[J]. 微创泌尿外科杂志, 2018, 7(1): 55-60.
Wang Jukun, Shang Zhenhua, Cui Bo, Wang Xu, Yan Hao, Wang Qi, Cui Xin, Li Jin, Jia Chunsong, Ou Tongwen. Relationship between neutrophil/lymphocyte ratio and prognosis of non-muscular invasive bladder cancer. JOURNAL OF MINIMALLY INVASIVE UROLOGY, 2018, 7(1): 55-60.
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