Application of Estimation Equations for Glomerular Filtration Rate in Renal Tumor Patients
Zhang Wen1, Wang Gang2 Li Ningchen2 Yan Jingmin3 Wang Yulin1
1Department of Urology, Beijing Fengtai Hospital, Beijing 100070, China; 2Peking University Wujieping Urology Medical Center, Peking University Shougang Hospital; 3Department of Urology, The Airforce General Hospital
Abstract：Objective: To evaluate the applicability of CKD-EPI equation, simplified MDRD eqution and refitted MDRD equation to Chinese to predicate glomerular filtration rate (GFR) in Chinese patient with renal tumor. Methods: A total of 73 renal tumor patients were enrolled. 99mTc-DTPA-GFR was used as golden standard. The value of estimated GFR gained through CKD-EPI equation, simplified MDRD eqution and refitted MDRD equation to Chinese were compared to rGFR. Results: There were significant correlations among eGFR and rGFR respectively(r=0.658,P=0.001; r=0.806,P=0.000; r=0.795,P=0.000). There were no significant difference of the area under ROC curve between the two points with 90 or 60 ml·min-1·1.73 m-2 as the diagnostic cut-off point. Conclusions: All of these three equations could be used as an efficient tool to evaluate renal function of renal tumor patients.
张文,王刚,李宁忱,严景民,王玉林. 三种肾小球滤过率预测公式在肾脏肿瘤患者肾功能评估中的应用[J]. 微创泌尿外科杂志, 2015, 4(2): 99-102.
Zhang Wen, Wang Gang Li Ningchen Yan Jingmin Wang Yulin. Application of Estimation Equations for Glomerular Filtration Rate in Renal Tumor Patients. JOURNAL OF MINIMALLY INVASIVE UROLOGY, 2015, 4(2): 99-102.
[1]Chow WH, Devesa SS, Warren JL, et al. Rising incidence of renal cell cancer in the United States. JAMA,1999,281(17):1628-1631. [2]马迎春,左力,张春丽,等. 肾动态显像法测定肾小球过率在肾功能不同分期中的适用性. 中华医学杂志,2006,86(5):351-353. [3]Levey AS, Stevens LA, Schmid CH, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med, 2009,150(9):604-612. [4]Hoy WE, Wang Z, Baker PR, et al. Reduction in natural death and renal failure from a systematic screening and treatment program in an Australian Aboriginal community. Kidney Int Suppl,2003(83):S66-S73. [5]Rule AD, Larson TS, Bergstralh EJ, et al. Using serum creatinine to estimate glomerular filtration rate: accuracy in good health and in chronic kidney disease. Ann Intern Med, 2004,141(12):929-937. [6]全国eGFR课题协作组. MDRD方程在我国慢性肾脏病患者中的改良和评估. 中华肾脏病杂志,2006,22(10):589-592. [7]Nguyen MM, Gill IS, Ellison LM. The evolving presentation of renal carcinoma in the United States: trends from the Surveillance, Epidemiology, and End Results program. J Urol,2006,176(6 Pt 1):2397-2400. [8]Kopple JD. National kidney foundation K/DOQI clinical practice guidelines for nutrition in chronic renal failure. Am J Kidney Dis,2001,37(1 Suppl 2):S66-S70. [9]Garg AX, Kiberd BA, Clark WF, et al. Albuminuria and renal insufficiency prevalence guides population screening: results from the NHANES III. Kidney Int,2002,61(6):2165-2175. [10]张路霞,左力,徐国宾,等. 北京市石景山地区中老年人群中慢性肾脏病的流行病学研究. 中华肾脏病杂志,2006,22(2):67-71. [11]Go AS, Chertow GM, Fan D, et al. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med,2004,351(13):1296-1305. [12]Huang WC, Elkin EB, Levey AS, et al. Partial nephrectomy versus radical nephrectomy in patients with small renal tumors--is there a difference in mortality and cardiovascular outcomes? J Urol, 2009,181(1):55-62. [13]Stevens LA, Levey AS. Measurement of kidney function. Med Clin North Am, 2005,89(3):457-473. [14]Stevens LA, Li S, Kurella TM, et al. Comparison of the CKD Epidemiology Collaboration (CKD-EPI) and Modification of Diet in Renal Disease (MDRD) study equations: risk factors for and complications of CKD and mortality in the Kidney Early Evaluation Program (KEEP). Am J Kidney Dis, 2011,57(3 Suppl 2):S9-S16. [15]Levey AS, Stevens LA, Schmid CH, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med, 2009,150(9):604-612.
