Abstract：Objective:To assess and compare the security, efficacy of percutaneous nephrolithotomy(PCNL) and Flexible ureteroscopic lithotripsy(FURL). Methods:We searched PubMed, CNKI, ScineceDirect, Ovid, EBSCO, CBM and collected relevant literature published beteen 2003-2012. Meta-analysis was performed using the RevMan 5.2 software. Results:Eleven non-randomized controlled trials were inclued. The results of meta-analysis showed that PCNL was better than FURL in stones clearance (OR=0.51, 95%CI[0.36, 0.72], P=0.000 2), But FURL was better the Mean operative time (MD=17.06, 95%CI[2.94, 31.18], P=0.02), the duration of hospitalization(MD=-1.51, [-1.98,-1.03], P＜0.000 01), the postoperative bleeding (OR=0.31, 95%CI[0.05, 1.93], P=0.21), the postoperative pyrexia (OR=1.35, 95%CI[0.51, 3.52], P=0.54), the postoperative leakage of urine (OR=0.26, 95%CI[0.03, 2.45], P=0.24). Conclusions:Flexible ureteroscopic lithotripsy is safe,compared to percutaneous nephrolithotomy, this surgery has some advantages on avoiding compliactions.
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