Abstract：Objective: To investigate prevention measures of urine-induced sepsis after flexible ureteroscope holmium laser lithotripsy in order to reduce the incidence. Methods: The clinical data of 5 cases of urine-induced sepsis after flexible ureteroscope holmium laser lithotripsy were retrospectively analyzed. Two patients were diagnosed as having pyelolith, and three having calyceal calculus. Stone size was ranged from 1.5-2.5 cm. Blood routine test, hepatorenal function, chest radiography, electrocardiogram before operation were normal. Urinalysis of three patients was normal, and leukocyte count of urinalysis was 5-12/Hp in two patients. Urine culture before operation was negative in 4 patients. The first urine culture was positive for Escherichia coli in one patient, and re-examination of urine culture was negative after sensitive antibiotic administration. All patients were subjected to flexible ureteroscope holmium laser lithotripsy under general anesthesia. Results: Five patients had sepsis to varying degrees after operation and cured after sensitive antibiotic administration combined with symptomatic and supportive treatment. Conclusions: Urine-induced sepsis was one of the most serious complications. Sufficient preoperative preparation, control of operation time, postoperative monitoring closely and usage of sensitive antibiotic administration as soon as possiblewere key measures for preventing and treating urine-induced sepsis after flexible ureteroscope holmium laser lithotripsy.
