Abstract：Objective: To investigate the clinical and pathological features, prognosis and differential diagnosis of tubulocystic carcinoma of the kidney(TCC). Methods: Retrospectively analysis the clinical dataof a case of TCC and review pertinent literatures with statistical analysis. Results: TCC is a rare disease in clinic. Review pertinent literatures of 83 TCC cases, fifty-one of which was elected and analyzed with statistical methods. The results showed an average age of (57.43±16.07)years(range from18 to 94, median 61). The ratio of incidence between men and women was 8∶1.The tumor ranged in size from 0.2 to 17.0 cm in its greatest dimension with a mean size of (28±3.01)cm. By sex group, the age of onset and size of tumor showed no statistical difference. However, the age of onset was found to be significantly lower on patients with clinical symptoms (39.40±16.24 vs 59.39±14.95, P＜0.05). In our case, there showed no uniqueness in clinical and imaging features, with the pathological and Immunohistochemical observations matching the document description. A follow-up of 19months showed no recurrence and metastasisafter radical resection of right kidney. Conclusions: TCC is a rare entity of renal cell carcinoma with a male preponderance of 8∶1. There was no characteristic of clinical manifestation with other renal neoplasms. Confirmed diagnosis depends on the examination of pathology and immunoh is tochemistry. Surgical resection is the preferred treat ment of TCC, with favorable postoperative prognosis and low malignant potential.
孟令全,汪洋,朱耀峰,史本康. 肾管状囊性癌临床特点分析(附1例报告并文献复习)[J]. 微创泌尿外科杂志, 2014, 3(5): 277-282.
Meng Lingquan,Wang Yang,Zhu Yaofeng,Shi Benkang. Clinical features of tubulocystic carcinoma of the kidney: A case report with literature review. JOURNAL OF MINIMALLY INVASIVE UROLOGY, 2014, 3(5): 277-282.
[1]Masson P. Tumeurs Humaines 1955. Human Tumors, Histology,Diagnosis and Technique.2nd ed. Detroit:Wayne State University Press, 1970.chap 5. [2]Maclennan GT, Farrow GM, Bostwick DG, et al. Low-gradecollecting duct carainoma of the kidney:report of 13 casesof low-grade mucinous tubulocystic renal carcinoma ofpossible collecting duct origin.Urology, 1997, 50(5):679-684. [3]Amin MB, MacLennan GT, Paraf F, et al. Tubulocystic carcinomaof the kidney:clinicopathologic analysis of 29 cases of adistinctiverare subtype ofrenal carcinoma. Modern Pathology, 2004, 17:137A. [4]Amin MB, Maclennan GT, Gupta R, etal. Tubulocysticcarcinoma of the kidney:clinicopathologic analysis of 31cases of a distinctive rare subtype of renal cell carcinoma.Am J Surg Pathol, 2009, 33(3):384-392. [5]Azoulay S, Vieillefond A, Paraf F, et al. Tubulocystic carcinoma ofthe kidney:a new entity among renal tumors. Virchows Arch, 2007, 451(5):905-909. [6]Yang XJ, Zhou M, Hes O, et al. Tubulocystic carcinoma of thekidney:clinicopathologic and molecular characterization. Am J SurgPathol, 2008, 32(2):177-187. [7]Alexiev BA, Drachenberg CB. Tubulocystic carcinoma of the kidney:a histologic, immunohistochemical, and ultrastructural study. Virchows Arch, 2013, 462(5):575-581. [8]Deshmukh M, Shet T, Bakshi G, et al. Tubulocystic carcinoma ofkidney associated with papillary renal cell carcinoma. Indian J Pathol Microbiol, 2011, 54(1):127-130. [9]Kong MX, Hale C, Subietas-Mayol A, et al. Bilateral tubulocystic renal cell carcinomas in diabetic end-stage renal disease:first case report with cytogenetic and ultrastructural studies. Rare Tumors, 2013, 5(4):e57. Rare Tumors, 2013, 5(4):185-188. [10]Moses KA, Decaro JJ, Osunkoya AO, et al. Tubulocystic carcinoma of the kidney: a case report of natural history and long-term follow-up. ScientificWorldJournal, 2010, 10:586-589. [11]Zhang SH, Shi SF, Huang SF, et al. Clinical and pathologic features of tubulocystic carcinoma of kidney. Zhonghua Bing Li Xue Za Zhi, 2012, 41(8):543-546. [12]Hora M, Urge T, Eret V, et al. Tubulocystic renal carcinoma: a clinical perspective. World J Urol, 2011,29(3):349-354. [13]Bhullar JS, Thamboo T, Esuvaranathan K. Unique case of tubulocystic carcinoma of the kidney with sarcomatoid features: a new entity. Urology, 2011, 78 (5):1071-1072. [14]Al-Hussain TO, Cheng L, Zhang S, et al. Tubulocystic carcinoma of the kidney with poorly differentiated foci:a series of 3 cases with fluorescence in situ hybridization analysis. Hum Pathol, 2013, 44(7):1406-1411. [15]Shih-Hao Liu, Yen-Hwa Chang, Chin-Chen Pan. Tubulocystic carcinoma of the kidney. Urological Science, 2011, 22:157-159. [16]Khalaf I, El-Badawy N, Shawarby MA. Tubulocystic renal cell carcinoma, a rare tumor entity:Review of literature and report of a case. Afr J Urol, 2013, 19(1):1-6.[17]Quiroga-Garza G, Oviedo SP, Cuevas-Ocampo K, et al. Synchronous clear cell renalcell carcinoma and tubulocystic carcinoma:genetic evidenceof independent ontogenesis and implications of chromosomalimbalances in tumor progression. Diagnostic Pathology, 2012, 7:21. [18]Liu Q, Gao RL, Zhu JS. Tubulocystic carcinoma of the kidney.J Clin Exp Pathol, 2007, 23(4):483-485. [19]Zhang W, Han F, Li YJ, Zhuang J, Jiang YX.Clinical and pathological observation of tubulocystic Carcinoma of the Kidney.J Clin Exp Pathol, 2012, 28(1):81-83. [20]Wei L, Xue S, Zhou SG, et al.Clinical Analysisof aRareCaseof Renal TubiformCystocarcinoma.Clinical Misdiagnosis&Mistherapy, 2012, 25(5):57-58. [21]Xia FF, Xu L. Renal Tubular Cystic Carcinoma:One Case Report.Journal of Chinese Oncology, 2013, 19(10):822-824. [22]Xu J, Wang J, Jin M. A Case Report of renal Tubular Cystic Carcinoma. Chin J Pathol, 2013, 42(7):473-474. [23]Radhakrishnan A, MacLennan GT, Hennigar RA, et al. Ultrastructural and immunohistochemical appraisal of tubulocystic carcinoma of the kidney:histogenetic and diagnostic implications.ModPathol, 2005, 18(3):160. [24]Zhou M, Yang XJ, Lopez JI, et al. Renal tubulocystic carcinoma iscloselyrelatedtopapillaryrenal cell carcinoma:implicationsfor pathologic classification. AmJ Surg Pathol, 2009, 33(12) :1840-1849.
