肾细胞癌患者根治术后2~3期急性肾损伤发生危险因素研究

doi:10.19558/j.cnki.10-1020/r.2021.05.009

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摘要 目的:探讨肾细胞癌（RCC）患者根治术后2~3期急性肾损伤（AKI）发生危险因素。方法:回顾性分析2010年1月–2020年9月收治的460例行根治手术治疗RCC患者的临床资料,根据是否发生2~3期AKI分为两组,采用单因素和多因素法评价RCC患者根治术后发生2~3期AKI独立危险因素。结果:460例患者中术后发生AKI 1~3期例数分别为314例、21例、5例,占比分别为68.26%、4.57%、1.09%。单因素分析结果显示,合并T₂DM、高WBC计数及尿蛋白阳性均与RCC患者根治术后发生2~3期AKI有关（P<0.05）。多因素分析结果显示,合并T₂DM和高WBC计数均是RCC患者根治术后发生2~3期AKI的独立危险因素（P<0.05）。结论:RCC患者中合并T₂DM和高WBC计数人群根治术后更易发生2~3期AKI。

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	王远龙
	刘建洪
	孙懿
	张盼

关键词 ：肾细胞癌, 手术, 急性肾损伤, 危险因素

Abstract：Objective: To investigate the risk factors of AKI with stage 2-3 in RCC patients after radical operation. Methods: Clinical data of 460 RCC patients with HCC after radical operation were retrospectively chosen in the period from January 2010 to September 2020. All patients were grouped according to AKI with stage 2-3 or not and the independent risk factors of AKI with stage 2-3 in RCC patients after radical operation were evaluated by univariate and multivariate methods. Results: 460 patients included 314 cases with AKI stage 1 accounting for 68.26%, 4.57%, 21 cases with AKI stage 2 accounting for 4.57% and 5 cases with AKI stage 3 accounting for 1.09%respectively. Univariate analysis showed that T₂DM, high WBC count and positive urine protein were associated with RCC with stage 2-3 AKI after radical resection（P < 0.05）. Multivariate analysis showed that T₂DM and high WBC count were independent risk factors for stage 2-3 AKI in RCC patients（P < 0.05）. Conclusion: T₂DM and high WBC count in patients with RCC after radical operation are more likely to occur AKI with stage 2-3.

Key words： renal cell carcinoma operation acute kidney injury risk factors

收稿日期: 2021-01-13

通讯作者: 孙懿,103621862@qq.com

引用本文:

王远龙, 刘建洪, 孙懿, 张盼. 肾细胞癌患者根治术后2~3期急性肾损伤发生危险因素研究[J]. 微创泌尿外科杂志, 2021, 10(5): 331-334.
WANG Yuanlong, LIU Jianhong, SUN Yi, ZHANG Pan. Risk factors of AKI with stage 2-3 in RCC patients after radical operation. JOURNAL OF MINIMALLY INVASIVE UROLOGY, 2021, 10(5): 331-334.

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http://journal20.magtechjournal.com/Jwk_zgmnwk/CN/abstract/abstract1706.shtml 或 http://journal20.magtechjournal.com/Jwk_zgmnwk/CN/Y2021/V10/I5/331

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