Abstract:Objective: To explore the clinical features of calcium oxalate (CaOx) stones in Henan province, and provide clinical basis for early prevention and intervention of CaOx stones. Methods: This study retrospectively analyzed 258 patients with CaOx stones and 502 age - and gender-matched individuals without urolithiasis from September 2018 to September 2019. The single factor and the Logistic multi-factor regression analysis method were used to analyze the independent correlated risk factors of CaOx stones. Results: Multivariate logistic regression analysis showed that obesity (OR = 2.775, 95%CI: 1.413-5.449, P = 0.003), type 2 diabetes (OR = 2.005, 95%CI: 1.025-3.920, P = 0.042), and hyperuricemia (OR = 2.639, 95%CI: 1.560-4.466, P = 0.000) were correlated risk factors for CaOx stones. Conclusion: In this study, obesity, type 2 diabetes and hyperuricemia independently influenced the risk of CaOx stones in this region, and early intervention can effectively reduce the prevalence of CaOx stones in Henan province.
武佰锁, 卢永顺, 张静琦, 石言, 王锦波, 郭君毅. 豫北地区草酸钙肾结石的临床特征相关性分析[J]. 微创泌尿外科杂志, 2021, 10(3): 180-183.
WU Baisuo, LU Yongshun, ZHANG Jingqi, SHI Yan, WANG Jinbo, GUO Junyi. Correlation Analysis of Clinical Features of Calcium Oxalate Stones in North of Henan. JOURNAL OF MINIMALLY INVASIVE UROLOGY, 2021, 10(3): 180-183.
[1] SOROKIN I, MAMOULAKIS C, MIYAZAWA K, et al.Epidemiology of stone disease across the world. World J Urol, 2017,35(9):1301-1320.
[2] BAATIAH NY, ALHAZMI RB, ALBATHI FA, et al.Urolithiasis: prevalence, risk factors, and public awareness regarding dietary and lifestyle habits in jeddah, Saudi Arabia in 2017. Urol Ann, 2020,12(1):57-62.
[3] LIU YT, YANG PY, YANG YW, et al.The association of nephrolithiasis with metabolic syndrome and its components: a cross-sectional analysis. Ther Clin Risk Manag, 2017,13: 41-48.
[4] SCALES J, SMITH AC, HANLEY JM, et al.Prevalence of kidney stones in the United States. Eur Urol, 2012,62(1):160-165.
[5] ZENG Q, HE Y.Age-specific prevalence of kidney stones in Chinese urban inhabitants. Urolithiasis, 2013,41(1):91-93.
[6] YE Z, ZENG G, HUAN Y, et al.The status and characteristics of urinary stone composition in China. BJU Int, 2020,125(6):801-809.
[7] LIESKE JC, RULE AD, KRAMBECK AE, et al.Stone composition as a function of age and sex. Clin J Am Soc Nephrol, 2014,9(12):2141-2146.
[8] ALMANNIE RM, AL-NASSER KA, AL-BARRAQ KM, et al.The effect of the body mass index on the types of urinary tract stones. Urol Ann, 2020,12(1):42-48.
[9] CURHAN GC, WILLETT WC, RIMM EB, et al.Body size and risk of kidney stones. J Am Soc Nephrol, 1998,9(9):1645-1652.
[10] STROHMAIER WL, WROBEL BM, SCHUBERT G.Overweight, insulin resistance and blood pressure (parameters of the metabolic syndrome) in uric acid urolithiasis. Urol Res, 2012,40(2):171-175.
[11] IBA A, KOHJIMOTO Y, MORI T, et al.Insulin resistance increases the risk of urinary stone formation in a rat model of metabolic syndrome. BJU Int, 2010,106(10):1550-1554.
[12] 武佰锁,郭君毅,王锦波.代谢综合征与肾结石的相关性研究进展.微创泌尿外科杂志,2019,8(4):280-286.
[13] LIESKE JC, VEGA L, GETTMAN MT, et al.Diabetes mellitus and the risk of urinary tract stones: a population-based case-control study. Am J Kidney Dis, 2006,48(6):897-904.
[14] CHEN HS, SU LT, LIN SZ, et al.Increased risk of urinary tract calculi among patients with diabetes mellitus--a population-based cohort study. Urology, 2012,79(1):86-92.
[15] WEINBERG AE, PATEL CJ, CHERTOW GM, et al.Diabetic severity and risk of kidney stone disease. Eur Urol, 2014,65(1):242-247.
[16] 陈星,郭剑明,王国民,等.代谢综合征与泌尿系结石复发关系的研究.中华泌尿外科杂志,2015,36(8):624-627.
[17] COE FL.Hyperuricosuric calcium oxalate nephrolithiasis. Adv Exp Med Biol, 1980,128(5):439-450.
[18] MOE OW, XU L.Hyperuricosuric calcium urolithiasis. J Nephrol, 2018,31(2):189-196.